身體在對抗結核病時需要免疫反應，然而，結核病患周邊血液單核細胞球的活化

身体在对抗结核病时需要免疫反应，然而，结核病患周边血液单核细胞球的活化情形，目前仍不太清楚，这次研究目的在于探讨结核病患单核球及T淋巴球的活化情况。此研究纳入27名健康人及18名新诊断的结核病患；利用流式细胞仪测量单核球、CD4 T淋巴球、CD8 T淋巴球的人类白血球DR抗原。研究发现，结核病患CD8 T淋巴球在周边血液单核细胞球的比例低于对照组，结核病患血液循环CD8 T淋巴球的数目低于对照组；在结核病患中，人类白血球DR抗原阳性的单核球、CD4 T淋巴球，人类白血球DR抗原表现低于对照组。结论是，结核菌感染可能会影响单核球活化，也影响到CD4 T淋巴球、CD8 T淋巴球

身体在对抗结核病时需要免疫反应，然而，结核病患周边血液单核细胞球的活化情形，目前仍不太清楚，这次研究目的在于探讨结核病患单核球及T淋巴球的活化情况。 此研究纳入27名健康人及18名新诊断的结核病患;利用流式细胞仪测量单核球、CD4 T淋巴球、CD8 T淋巴球的人类白血球DR抗原。 研究发现，结核病患CD8 T淋巴球在周边血液单核细胞球的比例低于对照组，结核病患血液循环CD8 T淋巴球的数目低于对照组;在结核病患中，人类白血球DR抗原阳性的单核球、CD4 T淋巴球，人类白血球DR抗原表现低于对照组。 结论是，结核菌感染可能会影响单核球活化，也影响到CD4 T淋巴球、CD8 T淋巴球

The body needs an immune response to fight against tuberculosis. However, the activation of monocytes in the peripheral blood of patients with tuberculosis is still unclear. The purpose of this study is to explore the activation of monocytes and T lymphocytes in patients with tuberculosis. In this study, 27 healthy people and 18 newly diagnosed tuberculosis patients were included; the DR antigens of monocytes, CD4 T lymphocytes and CD8 T lymphocytes were measured by flow cytometry. It was found that the proportion of CD8 T lymphocytes in peripheral blood mononuclear cells of tuberculosis patients was lower than that of the control group, and the number of CD8 T lymphocytes in blood circulation of tuberculosis patients was lower than that of the control group. In tuberculosis patients, the expression of DR antigen of human leukocytes and CD4 T lymphocytes were lower than that of the control group. The conclusion is that the infection of TB may affect the activation of monocytes, CD4 T lymphocytes and CD8 T lymphocytes<br>